Comparative toxicity of isoflurane, halothane, fluroxene and diethyl ether in human volunteers
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منابع مشابه
ISOFLURANE VERSUS HALOTHANE Physical properties of Isoflurane compared to Halothane
Isoflurane is a haloginated ether, is stable when stored and is presented as 99.9% pure product. The absence of a preservative make vaporisation more efficient and it is very unlikely that moving parts of the vaporiser will stick. The physical properties of isoflurane are similar to those of halothane. The minimum alveolar concentration (MAC) of isoflurane in the different target species is det...
متن کاملPharmacokinetics of Halothane and Ether.
In 1847 John Snow wrote: "It will be at once admitted that the medical practitioner ought to be acquainted with the strength of the various compounds which he applies as remedial agents, and that he ought, if possible, to be able to regulate their potency. The compound of ether vapour and air is no exception to this rule, although it might be supposed to form one, as the practitioner stands by ...
متن کاملTail clamp responses in stomatin knockout mice compared with mobility assays in Caenorhabditis elegans during exposure to diethyl ether, halothane, and isoflurane.
BACKGROUND The gene unc-1 plays a central role in determining volatile anesthetic sensitivity in Caenorhabditis elegans. Because different unc-1 alleles cause strikingly different phenotypes in different volatile anesthetics, the UNC-1 protein is a candidate to directly interact with volatile anesthetics. UNC-1 is a close homologue of the mammalian protein stomatin, for which a mouse knockout w...
متن کاملDiluted isoflurane as a suitable alternative for diethyl ether for rat anaesthesia in regular toxicology studies.
Despite its explosive properties and toxicity to both animals and humans, diethyl ether is an agent long used in Japan in the anaesthesia jar method of rat anaesthetises. However, in response to a recent report from the Science Council of Japan condemning diethyl ether as acceptable practice, we searched for an alternative rat anaesthesia method that provided data continuous with pre-existing r...
متن کاملThe action of the halothane-diethyl ether azeotropic mixture on experimental animals.
MANY mixtures of volatile anaesthetics have been -used in the past with some success, but they are difficult to handle in the modern anaesthetic apparatus. Because of the differences in the boiling points of the components of these mixtures, they volatilize at different rates and therefore it is almost impossible to know their concentration in the anaesthetic mixture administered to the patient...
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1973
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03027173